In Vitro Enzyme Inhibitory Properties, Secondary Metabolite Profiles and Multivariate Analysis of Five Seaweeds

Marine Drugs

József Jekő¹  Zoltán Cziáky¹  Gokhan Zengin²  Kouadio Ibrahime Sinan²  Kannan RR Rengasamy³  Doo Hwan Kim³  NabeelahBibi Sadeer⁴  Alina Diuzheva⁵  Kishneth Palaniveloo⁶  Mohamad Fawzi Mahomoodally⁷ 

[1] Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4400 Nyíregyháza, Hungary;Department of Biology, Science Faculty, Selcuk University, Konya 42250, Turkey;Department of Bioresources and Food Science, Konkuk University, Seoul 05029, Korea;Department of Health Sciences, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius;Faculty of Forestry and Wood Sciences, Czech University of Life Sciences, 16500 Prague, Czech Republic;Institute of Ocean and Earth Sciences, Institute for Advanced Studies Building, University of Malaya, Wilayah Persekutuan Kuala Lumpur 50603, Malaysia;Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam;

关键词: seaweeds;    antioxidants;    tyrosinase;    bioactive metabolites;    biological activities;   

DOI  :  10.3390/md18040198

来源: DOAJ

【 摘 要 】

Seaweeds have been exploited as both food products and therapeutics to manage human ailments for centuries. This study investigated the metabolite profile of five seaweeds (Halimeda spp., Spyridia hypnoides (Bory de Saint-Vincent) Papenfuss, Valoniopsis pachynema (G. Martens) Børgesen, Gracilaria fergusonii J. Agardh and Amphiroa anceps (Lamarck) Decaisne using ultra-high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (UHPLC-ESI-MS/MS). Furthermore, these seaweeds were assessed for antioxidant and inhibitory effects against α-amylase, α-glucosidase, acetyl-cholinesterase (AChE), butyryl-cholinesterase (BChE) and tyrosinase. Valoniopsis pachynema and A. anceps yielded the highest flavonoid (4.30 ± 0.29 mg RE/g) and phenolic content (7.83 ± 0.08 mg RE/g), respectively. Additionally, A. anceps exhibited significant antioxidant properties with all assays and significantly depressed BChE (IC₅₀ = 6.68 ± 0.83 mg/mL) and α-amylase activities (IC₅₀ = 5.34 ± 0.14 mg/mL). Interestingly, the five seaweeds revealed potent inhibitory effects against tyrosinase activity. In conclusion, A. anceps might be considered as a key source of phytoantioxidants and a potential candidate to develop nutritional supplements. Besides, the five tested seaweeds warrant further study and may be exploited as promising natural sources for managing hyperpigmentation.

【 授权许可】

Unknown