(E)-1-(2′,4′-Dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one

Molbank

Mahamuda Sultana Shaik¹  Srinivasa Babu Puttagunta¹  Afzal Shaik¹ 

[1] Department of Pharmaceutical Chemistry, Vignan Pharmacy College, Vadlamudi-522 213, Guntur, Andhra Pradesh, India;

关键词: thiazole;    chalcone;    acid-catalyzed condensation;    (E)-1-(2′,4′-dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one;   

DOI  :  10.3390/M1019

来源: DOAJ

【 摘 要 】

Thiazole and chalcone motifs are of research interest to medicinal chemists due to their array of synthetic and biological utility. Hence, in the present study we intended to prepare (E)-1-(2′,4′-dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one (3c) containing both these scaffolds. The compound 3c was synthesized by the acid-catalyzed condensation of 2,4-dimethyl-5-acetylthiazole with 2,4-difluorobenzaldehyde. Purification and characterization of the compound were carried out by recrystallization and spectral techniques including UV, IR, 1H-NMR, 13C-NMR, Mass spectrometry and X-ray powdered diffractometry. The molecule 3c was successfully synthesized, purified, and characterized.

【 授权许可】

Unknown