Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives

Molecules

Vytautas Mickevičius⁴  Aušra Voskienė⁴  Ilona Jonuškienė⁴  Ramūnė Kolosej⁴  Jūratė Šiug𗻚itė²  Petras Rimantas Venskutonis¹  Rita Kazernavičiūtė¹  Zita Brazienė³ 

[1] Department of Food Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania; E-Mails:;Lithuanian University of Health Sciences, Veterinary Academy, Tilžės 18, LT-47181 Kaunas, Lithuania; E-Mail:;Lithuanian Research Centre for Agriculture and Forestry, Rumokai Experimental Station, Klausučiai, 70462 Vilkaviškis Distr., Lithuania; E-Mail:;Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania; E-Mails:

关键词: N-phenyl-N-thiocarbamoyl-β-alanine;    Hantzsch synthesis;    thiazole;    hydrazone;    biological activity;   

DOI  :  10.3390/molecules181215000

来源: mdpi

【 摘 要 】

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.