A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

Molecules

Yan-Bo Yu¹  Hong-Liang Chen¹  Li-Yi Wang¹  Xin-Zheng Chen¹ 

[1] Department of Applied Chemistry, China Agricultural University, 100193, Beijing, China

关键词: thiazole;    thiazoline;    manganese dioxide;    oxidation;   

DOI  :  10.3390/molecules14124858

来源: mdpi

【 摘 要 】

Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO₂) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.