Obesity, Inflammation, and Mortality in COVID-19: An Observational Study from the Public Health Care System of New York City

Journal of Clinical Medicine

Shankar Srinivasan¹  Ryad Ali¹  Dimitrios Karamanis¹  Colin Cha-Fong²  Kenneth Hupart²  Michail Kladas²  Leonidas Palaiodimos²  Jeremy Sperling²  Sahana Parthasarathy²  Damianos G. Kokkinidis²  Natalia Chamorro-Pareja²  Michael Chang²  Robert T. Faillace²  Nichola Davis²  Sharanjit Kaur²  Preeti Kishore²  Hugo O. Teo² 

[1] Department of Health Informatics, Rutgers School of Health Professions, Newark, NJ 07107, USA;NYC Health + Hospitals, New York, NY 10461, USA;

关键词: obesity;    body mass index;    BMI;    COVID-19;    New York;    retrospective;   

DOI  :  10.3390/jcm11030622

来源: DOAJ

【 摘 要 】

Severe obesity increases the risk for negative outcomes in patients with coronavirus disease 2019 (COVID-19). Our objectives were to investigate the effect of BMI on in-hospital outcomes in our New York City Health and Hospitals’ ethnically diverse population, further explore this effect by age, sex, race/ethnicity, and timing of admission, and, given the relationship between COVID-19 and hyperinflammation, assess the concentrations of markers of systemic inflammation in different BMI groups. A retrospective study was conducted in hospitalized patients with COVID-19 in the public health care system of New York City from 1 March 2020 to 31 October 2020. A total of 8833 patients were included in this analysis (women: 3593, median age: 62 years). The median body mass index (BMI) was 27.9 kg/m². Both overweight and obesity were independently associated with in-hospital death. The association of overweight and obesity with death appeared to be stronger in men, younger patients, and individuals of Hispanic ethnicity. We did not observe higher concentrations of inflammatory markers in patients with obesity as compared to those without obesity. In conclusion, overweight and obesity were independently associated with in-hospital death. Obesity was not associated with higher concentrations of inflammatory markers.

【 授权许可】

Unknown