Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes

Microorganisms

LaraR. Dugas¹  BrianT. Layden²  Yuval Eisenberg²  Elena Barengolts²  Medha Priyadarshini²  GeorgeE. Chlipala³  StefanJ. Green⁴ 

[1] Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL 60153, USA;Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA;Research Informatics Core, Research Resources Center, University of Illinois, Chicago, IL 60612, USA;Sequencing Core, Research Resources Center, University of Illinois, Chicago, IL 60612, USA;

关键词: gut microbiota;    BMI;    body mass index;    CD14;    cluster of differentiation 14 protein;    EndoCab;    endotoxin core antibody;    LBP;    lipopolysaccharide-binding protein;    SCFA;    short-chain fatty acids;    zonulin;    butyric;    propionic;    obesity;    type 2 diabetes mellitus;    African American men;    cortisol;   

DOI  :  10.3390/microorganisms7090320

来源: DOAJ

【 摘 要 】

Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (n = 75). The main outcomes included fecal microbial community structure (16S rRNA), gut permeability biomarkers (ELISA), and short-chain fatty acids (SCFAs, metabolome analysis). These outcomes were compared between obese and non-obese men, after adjusting for age. The results showed that lipopolysaccharide-binding protein (LBP), the ratio of LBP to CD14 (LBP/CD14), and SCFAs (propionic, butyric, isovaleric) were higher in obese (n = 41, age 58 years, BMI 36 kg/m²) versus non-obese (n = 34, age 55 years, BMI 26 kg/m²) men. BMI correlated positively with LBP, LBP/CD14 (p < 0.05 for both) and SCFAs (propionic, butyric, isovaleric, p < 0.01 for all). In the regression analysis, LBP, LBP/CD14, propionic and butyric acids were independent determinants of BMI. The study showed for the first time that selected microbiota biomarkers (LBP, LBP/CD14, propionic and butyric acids) together with several other relevant risks explained 39%−47% of BMI variability, emphasizing that factors other than microbiota-related biomarkers could be important. Further research is needed to provide clinical and mechanistic insight into microbiota biomarkers and their utility for diagnostic and therapeutic purposes.

【 授权许可】

Unknown