Simulative Investigation of Different DLD Microsystem Designs with Increased Reynolds Numbers Using a Two-Way Coupled IBM-CFD/6-DOF Approach

Processes

Andreas Dietzel¹  Jonathan Kottmeier²  Arno Kwade³  Maike S. Wullenweber³  Ingo Kampen³ 

[1] Center of Pharmaceutical Engineering (PVZ), TU Braunschweig, 38106 Braunschweig, Germany;Institute for Microtechology, TU Braunschweig, 38124 Braunschweig, Germany;Institute for Particle Technology, TU Braunschweig, 38104 Braunschweig, Germany;

关键词: deterministic lateral displacement;    microfluidics;    size-dependent fractionation;    high throughput;    Reynolds number;    immersed boundary method;   

DOI  :  10.3390/pr10020403

来源: DOAJ

【 摘 要 】

Deterministic lateral displacement (DLD) microsystems are suitable for the size fractionation of particle suspensions in the size range of 0.1 to 10 µm. To be able to fractionate real particles beyond a laboratory scale, these systems have to be designed for higher throughputs. High flow resistances and increasing the clogging of the systems impose substantial challenges for industrial operation. Simulative parameter studies are suitable for improving the design of the systems; for example, the position and shape of the posts. A high-resolution, two-way coupled 6-DOF CFD-DEM approach was used to study the flow and particle behavior of different post shapes (circular and triangular) and post sizes at different Reynolds numbers. The results were compared with the classical first streamline width theory. It was shown that the streamline theory does not account for all effects responsible for the separation. Furthermore, a shift in the critical particle diameter to smaller values could be obtained when increasing the Reynolds number and also when using triangular posts with reduced post sizes compared to the post spacing. These findings can help to improve the efficiency of the systems as the post spacing could be extended, thus reducing the flow resistance and the probability of clogging.

【 授权许可】

Unknown