Neurotrophic Factors in Experimental Cerebral Acanthamoebiasis

International Journal of Molecular Sciences

Patrycja Kapczuk¹  Irena Baranowska-Bosiacka¹  Natalia Łanocha-Arendarczyk²  Karolina Kot²  Aleksandra Łanocha³  Danuta Izabela Kosik-Bogacka⁴ 

[1] Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland;Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland;Department of Haematology and Transplantology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland;Independent Laboratory of Pharmaceutical Botany, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland;

关键词: Acanthamoeba spp.;    brain-derived neurotrophic factor;    nerve growth factor;    neurotrophin-3;    neurotrophin-4;    cerebral cortex;   

DOI  :  10.3390/ijms23094931

来源: DOAJ

【 摘 要 】

To date, no studies have addressed the role of neurotrophins (NTs) in Acanthamoeba spp. infections in the brain. Thus, to clarify the role of NTs in the cerebral cortex and hippocampus during experimental acanthamoebiasis in relation to the host immune status, the purpose of this study was to determine whether Acanthamoeba spp. may affect the concentration of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) in brain structures. Our results suggest that at the beginning of infection in immunocompetent hosts, BDNF and NT-3 may reflect an endogenous attempt at neuroprotection against Acanthamoeba spp. infection. We also observed a pro-inflammatory effect of NGF during acanthamoebiasis in immunosuppressed hosts. This may provide important information for understanding the development of cerebral acanthamoebiasis related to the immunological status of the host. However, the pathogenesis of brain acanthamoebiasis is still poorly understood and documented and, therefore, requires further research.

【 授权许可】

Unknown