期刊论文详细信息
Biomarker Research
Advances in targeted therapy for acute myeloid leukemia
Peter Y. Z. Jiang1  Yongping Song2  Jifeng Yu3  Hao Sun3  Xia Zhang3  Zhongxing Jiang3  Yingmei Li3 
[1] Department of Hematology and Oncology, The Everett Clinic and Providence Regional Cancer Partnership;The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital;The First Affiliated Hospital of Zhengzhou University;
关键词: Targeted therapy;    Gene mutation;    Acute myeloid leukemia (AML);   
DOI  :  10.1186/s40364-020-00196-2
来源: DOAJ
【 摘 要 】

Abstract Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than half of a century. Although much progress has been made toward improving treatment related mortality rate in the past few decades, long term overall survival has stagnated. Exciting developments of gene mutation-targeted therapeutic agents are now changing the landscape in AML treatment. New agents offer more clinical options for patients and also confer a more promising outcome. Since Midostaurin, a FLT3 inhibitor, was first approved by US FDA in 2017 as the first gene mutation-targeted therapeutic agent, an array of new gene mutation-targeted agents are now available for AML treatment. In this review, we will summarize the recent advances in gene mutation-targeted therapies for patients with AML.

【 授权许可】

Unknown   

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