Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma

Experimental Hematology & Oncology

Hui Zeng¹  Caiqin Xie²  Xian Li²  Wenbin Qian² 

[1] Department of Hematology, First Affiliated Hospital of Jiaxing University;Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University;

关键词: Peripheral T-cell lymphoma;    Molecular genetic characteristics;    Gene mutation;    Targeted therapy;   

DOI  :  10.1186/s40164-020-00188-w

来源: DOAJ

【 摘 要 】

Abstract Peripheral T-cell lymphomas (PTCLs) are biologically and clinically heterogeneous diseases almost all of which are associated with poor outcomes. Recent advances in gene expression profiling that helps in diagnosis and prognostication of different subtypes and next-generation sequencing have given new insights into the pathogenesis and molecular pathway of PTCL. Here, we focus on a broader description of mutational insights into the common subtypes of PTCL including PTCL not other specified type, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, and extra-nodal NK/T cell lymphoma, nasal type, and also present an overview of new targeted therapies currently in various stages of clinical trials.

【 授权许可】

Unknown