Sudden Cardiac Death—A New Insight Into Potentially Fatal Genetic Markers

Frontiers in Medicine

Ljubica Odak¹  Jasmina Ćatić²  Jozica Šikić³  Vjekoslav Radeljić⁴  Šime Manola⁴  Robert Nussbaum⁵  Swaroop Aradhya⁵  Tanja Sofrenović⁵  Matteo Vatta⁵  Jure Mirat⁸  Johannes Brachmann⁹  Dragan Primorac^1,10  Vitorio Perić^1,13  Vilim Molnar^1,13  Vid Matišić^1,13  Andrea Skelin^1,13 

[1] 0Children's Hospital Zagreb, Zagreb, Croatia;1Department of Cardiology, Clinical Hospital Dubrava, Zagreb, Croatia;2Department of Cardiology, Clinical Hospital Sveti Duh, Zagreb, Croatia;3Department of Cardiology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia;4Invitae, San Francisco, CA, United States;Eberly College of Science, The Pennsylvania State University, University Park, State College, Philadelphia, PA, United States;Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;Medical School REGIOMED, Coburg, Germany;Medical School, University of Mostar, Mostar, Bosnia and Herzegovina;Medical School, University of Rijeka, Rijeka, Croatia;Medical School, University of Split, Split, Croatia;St. Catherine Specialty Hospital, Zagreb, Croatia;The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, United States;

关键词: sudden cardiac death;    genes;    coronary artery disease;    cardiomyopathy;    professional athletes;   

DOI  :  10.3389/fmed.2021.647412

来源: DOAJ

【 摘 要 】

Sudden cardiac death (SCD) is an unexpected and dramatic event. It draws special attention especially in young, seemingly healthy athletes. Our scientific paper is based on the death of a young, 23-year-old professional footballer, who died on the football field after a two-year history of cardiac symptoms. In this study we analyzed clinical, ECG and laboratory data, as well as results of genetic testing analysis in family members. To elucidate potential genetic etiology of SCD in this family, our analysis included 294 genes related to various cardiac conditions.

【 授权许可】

Unknown