Sudden Cardiac Death—A New Insight Into Potentially Fatal Genetic Markers

Frontiers in Medicine

Vjekoslav Radeljić¹  Šime Manola¹  Jozica Šikić²  Jure Mirat³  Robert Nussbaum⁴  Tanja Sofrenović⁴  Swaroop Aradhya⁴  Matteo Vatta⁴  Johannes Brachmann⁵  Andrea Skelin⁶  Vilim Molnar⁶  Vitorio Perić⁶  Vid Matišić⁶  Ljubica Odak⁷  Jasmina Ćatić⁸  Dragan Primorac⁹ 

[1] Department of Cardiology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia;Department of Cardiology, Clinical Hospital Sveti Duh, Zagreb, Croatia;Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;Invitae, San Francisco, CA, United States;Medical School, University of Split, Split, Croatia;Medical School REGIOMED, Coburg, Germany;St. Catherine Specialty Hospital, Zagreb, Croatia;St. Catherine Specialty Hospital, Zagreb, Croatia;Children's Hospital Zagreb, Zagreb, Croatia;St. Catherine Specialty Hospital, Zagreb, Croatia;Department of Cardiology, Clinical Hospital Dubrava, Zagreb, Croatia;St. Catherine Specialty Hospital, Zagreb, Croatia;Eberly College of Science, The Pennsylvania State University, University Park, State College, Philadelphia, PA, United States;The Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, United States;Medical School, University of Split, Split, Croatia;Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;Medical School, University of Rijeka, Rijeka, Croatia;Medical School REGIOMED, Coburg, Germany;Medical School, University of Mostar, Mostar, Bosnia and Herzegovina;

关键词: sudden cardiac death;    genes;    coronary artery disease;    cardiomyopathy;    professional athletes;   

DOI  :  10.3389/fmed.2021.647412

来源: Frontiers

【 摘 要 】

Sudden cardiac death (SCD) is an unexpected and dramatic event. It draws special attention especially in young, seemingly healthy athletes. Our scientific paper is based on the death of a young, 23-year-old professional footballer, who died on the football field after a two-year history of cardiac symptoms. In this study we analyzed clinical, ECG and laboratory data, as well as results of genetic testing analysis in family members. To elucidate potential genetic etiology of SCD in this family, our analysis included 294 genes related to various cardiac conditions.

【 授权许可】

CC BY