Fatty acid methyl esters as a potential therapy against cerebral ischemia

Oilseeds and fats, crops and lipids

Lerner Francesca M.¹  Chen Joseph A.¹  Yin-Chieh Wu Celeste¹  Klein Daniel D.¹  Valido Stephen E.¹  Hui-Chao Lee Reggie¹  Goyanes Vasquez Juan Jose¹  Couto e Silva Alexandre¹  Wen Lin Hung¹  Neumann Jake T.² 

[1] Cerebral Vascular Disease Laboratories, Department of Neurology,University of Miami Miller School of Medicine;Department of Biomedical Sciences, West Virginia School ofOsteopathic Medicine;

关键词: Cerebral ischemia;    cerebral blood flow;    neuroprotection;    palmitic acid methyl ester;    protein arginine methyltransferase;   

DOI  :  10.1051/ocl/2015040

来源: DOAJ

【 摘 要 】

Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global and focal cerebral ischemia. The methyl esterification of fatty acids is not prominent in nature. However, it seems to have biological activity related to neuroprotection/vasodilation. We will discuss the etiology of cerebral ischemia such as stroke and cardiac arrest in terms of current and future treatment modalitiesas it relates to fatty acid-based therapies. This review is based on the meeting presentation at the “The Journées Chevreul, Lipids & Brain III 2015” in Paris on 16–18 March, 2015.

【 授权许可】

Unknown