Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas

Molecules

Ahmed K. EL-Ziaty¹  Amira A. El-Sayed²  Elsayed A. Elsayed²  AbdEl-Galil E. Amr³ 

[1] Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabi;Laboratory of Synthetic Organic Chemistry, Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt;;Pharmaceutical Chemistry Department, Drug Exploration &

关键词: cyanopyridone;    substituted pyridine;    pyridotriazine;    pyrazolopyridine;    thioxotriazopyridine;    anticancer activity;    HepG2;    HeLa;   

DOI  :  10.3390/molecules24101965

来源: DOAJ

【 摘 要 】

In this study, a series of newly synthesized substituted pyridine 9, 11−18, naphthpyridine derivative 10 and substituted pyrazolopyridines 19−23 by using cycnopyridone 8 as a starting material. Some of the synthesized candidates are evaluated as anticancer agents against different cancer cell lines. In vitro cytotoxic activities against hepatocellular and cervical carcinoma cell lines were evaluated using standard MTT assay. Different synthesized compounds exhibited potential in vitro cytotoxic activities against both HepG2 and HeLa cell lines. Furthermore, compared to standard positive control drugs, compounds 13 and 19 showed the most potent cytotoxic effect with IC₅₀ values of 8.78 ± 0.7, 5.16 ± 0.4 μg/mL, and 15.32 ± 1.2 and 4.26 ± 0.3 μg/mL for HepG2 and HeLa cells, respectively.

【 授权许可】

Unknown