Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems

Journal of the Brazilian Chemical Society

Tarik El-sayed Ali¹  Magdy Ahmed Ibrahim¹ 

[1] ,Ain Shams University Faculty of Education Department of ChemistryCairo,Egypt

关键词: chromone;    o-diamine;    triazolopyridone;    pyridotriazine;    pyridotriazepine;    antimicrobial activity;   

DOI  :  10.1590/S0103-50532010000600010

来源: SciELO

【 摘 要 】

Three series of novel fused nitrogen heterocyclic systems such as 1,2,4-triazolo[1,5-α ] pyridines (5-7 and 9), pyrido[1,2-b][1,2,4]triazines (10, 11, 13 and 15), and pyrido[1,2-b][1,2,4]triazepines (17, 18, 20 and 22) linked with a chromone moiety were synthesized from the key intermediate 1,6-diamino-(6-chloro-4-oxo-4H-chromen-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (4) with some electrophilic reagents. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened invitro for their antimicrobial activity. Compounds 7, 9 and 15 showed the highest activities when compared with the reference drugs.

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