A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor

Molecules

Noha M. Helmy¹  Fatma E. M. El-Baih¹  Monirah A. Al-Alshaikh¹ 

[1] ¹Women Students-Medical Studies & Sciences Sections, Chemistry Department, College of Science, King Saud University, Riyadh, KSA, P.O. Box 22452, Riyadh 11495, Saudi Arabia ²Department of Chemistry, Faculty of Science, University of Kuwait, Safat 13060, Kuwait

关键词: malononitrile dimer;    arlymethylenemalononitrile;    benzylidenemalononitrile;    pyrazolopyridine;   

DOI  :  10.3390/molecules16010298

来源: mdpi

【 摘 要 】

The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.