Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis

Applied Sciences

WasimS. Khan¹  Achi Kamaraj²  Harry Kyriacou² 

[1] Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK;School of Clinical Medicine, University of Cambridge, Cambridge CB2 0QQ, UK;

关键词: antibiotic;    scaffold;    bone substitute;    bone graft;    osteomyelitis;    orthopaedics;   

DOI  :  10.3390/app10072244

来源: DOAJ

【 摘 要 】

Osteomyelitis is a devasting disease caused by the infection of bone tissue and is associated with significant morbidity and mortality. It is treated with antibiotic therapy and surgical debridement. A high dose of systemic antibiotics is often required due to poor bone penetration and this is often associated with unacceptable side-effects. To overcome this; local; implantable antibiotic carriers such as polymethyl methacrylate have been developed. However; this is a non-biodegradable material that requires a second surgery to be removed. As a result; attention has shifted to new antibiotic-eluting scaffolds which can be created with a range of unique properties. The purpose of this review is to assess the level of evidence that exists for these novel local treatments. Although this field is still developing; these strategies seem promising and provide hope for the future treatment of chronic osteomyelitis.

【 授权许可】

Unknown