Biological aspects to enhance fracture healing

EFORT Open Reviews

article

Paul L Rodham¹  Vasileios P Giannoudis¹  Nikolaos K Kanakaris¹  Peter V Giannoudis¹ 

[1] Academic Department of Trauma & Orthopaedics;Department of Trauma & Orthopaedics, University of Leeds

关键词: bone substitute;    fracture healing;    non-union;    bone graft;   

DOI  :  10.1530/EOR-23-0047

学科分类：神经科学

来源: The British Editorial Society of Bone & Joint Surgery

【 摘 要 】

The ability to enhance fracture healing is paramount in modern orthopaedic trauma, particularly in the management of challenging cases including peri-prosthetic fractures, non-union and acute bone loss. Materials utilised in enhancing fracture healing should ideally be osteogenic, osteoinductive, osteoconductive, and facilitate vascular in-growth. Autologous bone graft remains the gold standard, providing all of these qualities. Limitations to this technique include low graft volume and donor site morbidity, with alternative techniques including the use of allograft or xenograft. Artificial scaffolds can provide an osteoconductive construct, however fail to provide an osteoinductive stimulus, and frequently have poor mechanical properties. Recombinant bone morphogenetic proteins can provide an osteoinductive stimulus; however, their licencing is limited and larger studies are required to clarify their role. For recalcitricant non-unions or high-risk cases, the use of composite graft combining the above techniques provides the highest chances of successfully achieving bony union.

【 授权许可】

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