Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials

Materials

Robinder S. Dhillon¹ 

[1] The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14623, USA; E-Mail:

关键词: Parathyroid Hormone (PTH);    teriparatide;    osseointegration;    bio-integration;    fracture healing;    non-union;    allograft repair;    biomaterials;   

DOI  :  10.3390/ma4061117

来源: mdpi

【 摘 要 】

Critically sized large bone defects commonly result from trauma, radical tumor resections or infections. Currently, massive allografting remain as the clinical standard to treat these critical defects. Unfortunately, allograft healing is limited by the lack of osteogenesis and bio-integration of the graft to the host bone. Based on its widely studied anabolic effects on the bone, we have proposed that teriparatide [recombinant parathyroid hormone (PTH_1–34)] could be an effective adjuvant for massive allograft healing. In support of this theory, here we review studies that have demonstrated that intermittent PTH_1–34 treatment enhances and accelerates the skeletal repair process via a number of mechanisms including: effects on mesenchymal stem cells (MSC), angiogenesis, chondrogenesis, bone formation and remodeling. We also review the current literature on the effects of PTH_1–34 therapy on bone healing, and discuss this drug’s long term potential as an adjuvant for endogenous tissue engineering.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.