The potential of carbonate apatite as an alternative bone substitute material

Medical Journal of Indonesia

Bambang Suharno¹  Pancar Muhammad Pribadi¹  Sugeng Supriadi²  Ahmad Jabir Rahyussalim³  Aldo Fransiskus Marsetio³ 

[1] Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Depok;Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok;Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta;

关键词: bone graft;    bone substitute;    bone scaffold;    calcium phosphate;    carbonate apatite;    orthopedic biomaterials;   

DOI  :  10.13181/mji.v28i1.2681

来源: DOAJ

【 摘 要 】

Bone reconstructive surgery has become a common procedure, and bone transplantation has become the second most frequently performed tissue transplantation procedure worldwide. Therefore, the need for bone substitute materials has increased. Artificial bone substitutes exhibit osteoconductive properties and feature several advantages, including abundant resources, low cost, and low donor site morbidity. Carbonate apatite (CO3Ap) is a calcium phosphate ceramic that can be used as a synthetic bone graft. The carbonate content of this ceramic is similar to that of bone apatite. In this review, we show that carbonate apatite can be degraded given its chemical reactivity in a weakly acidic environment and through osteoclast resorption. Moreover, it is osteoconductive and promotes bone tissue formation without fibrotic tissue formation. Additionally, microstructural analysis revealed that new bone tissue is formed within the bone graft itself.

【 授权许可】

Unknown