Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection

International Journal of Infectious Diseases

Kathrine Agergård Kaspersen¹  Dorte Kinggaard Holm²  Ole Birger Vestager Pedersen³  Sisse Rye Ostrowski⁴  Lotte Hindhede⁵  Tyra Grove Krause⁶  Bo Langhoff Hønge⁷  Lene Holm Harritshøj⁷  Susanne Gjørup Sækmose⁷  Susan Mikkelsen⁷  Charlotte Sværke Jørgensen⁸  Anna Christine Nilsson⁸  Erik Sørensen⁹  Bitten Aagaard⁹  Henrik Hjalgrim^1,10  Henrik Ullum^1,11  Christian Erikstrup^1,12 

[1] Corresponding author. Bo Langhoff Hønge, Department of Clinical Immunology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N;Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Roskilde, Denmark;Danish Cancer Society Research Centre, Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Denmark;Department of Clinical Medicine, Copenhagen University, Denmark;Department of Infectious Diseases, Aarhus University Hospital, Denmark;Department of Clinical Immunology, Aalborg University Hospital, Denmark;Department of Clinical Immunology, Aarhus University Hospital, Denmark;Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Denmark;Department of Clinical Immunology, Odense University Hospital, Denmark;Department of Clinical Immunology, Zealand University Hospital, Denmark;Department of Epidemiology Research, Statens Serum Institut, Denmark;Department of Virus and Microbiological Species Diagnostics, Statens Serum Institut, Denmark;

关键词: SARS-CoV-2;    seroprevalence;    Wantai;    sensitivity;    blood donors;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 Methods: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa). Results: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039–0.262)). Conclusion: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.

【 授权许可】

Unknown