Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study

Viruses

The SEROCoV-WORK + Study Group¹  Delphine Courvoisier²  Idris Guessous³  Omar Kherad⁴  Jean-François Balavoine⁴  Didier Pittet⁴  Simon Regard⁵  Laurent Kaiser⁶  Roxane Dumont⁷  Richard Dubos⁷  María-Eugenia Zaballa⁷  Hélène Baysson⁷  Lakshmi Krishna Menon⁷  Ania Wisniak⁷  Andrew S. Azman⁷  Silvia Stringhini⁷  Nick Pullen⁷ 

[1] ;Care Quality Division, Medical and Quality Directorate, Geneva University Hospitals, 1211 Geneva, Switzerland;Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland;Department of Medicine, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland;Department of Security, Population and Health, General Health Directorate, Canton of Geneva, 1211 Geneva, Switzerland;Division of Laboratory Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland;Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland;

关键词: COVID-19;    SARS-CoV-2;    nursing homes;    viral spread;    transmission;    seroprevalence;   

DOI  :  10.3390/v14010043

来源: DOAJ

【 摘 要 】

The burden of COVID-19 has disproportionately impacted the elderly, who are at increased risk of severe disease, hospitalization, and death. This cross-sectional study aimed to assess the association between SARS-CoV-2 seroprevalence among nursing home staff, and cumulative incidence rates of COVID-19 cases, hospitalizations, and deaths among residents. Staff seroprevalence was estimated within the SEROCoV-WORK+ study between May and September 2020 across 29 nursing homes in Geneva, Switzerland. Data on nursing home residents were obtained from the canton of Geneva for the period between March and August 2020. Associations were assessed using Spearman’s correlation coefficient and quasi-Poisson regression models. Overall, seroprevalence among staff ranged between 0 and 31.4%, with a median of 8.3%. A positive association was found between staff seroprevalence and resident cumulative incidence of COVID-19 cases (correlation coefficient R = 0.72, 95%CI 0.45–0.87; incidence rate ratio [IRR] = 1.10, 95%CI 1.07–1.17), hospitalizations (R = 0.59, 95%CI 0.25–0.80; IRR = 1.09, 95%CI 1.05–1.13), and deaths (R = 0.71, 95%CI 0.44–0.86; IRR = 1.12, 95%CI 1.07–1.18). Our results suggest that SARS-CoV-2 transmission between staff and residents may contribute to the spread of the virus within nursing homes. Awareness among nursing home professionals of their likely role in the spread of SARS-CoV-2 has the potential to increase vaccination coverage and prevent unnecessary deaths due to COVID-19.

【 授权许可】

Unknown