Profluorescent substrates for the screening of olefin metathesis catalysts

Beilstein Journal of Organic Chemistry

Raphael Reuter¹  Thomas R. Ward¹ 

[1] Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland;

关键词: fluorescence;    microplate screening;    ring closing metathesis;   

DOI  :  10.3762/bjoc.11.203

来源: DOAJ

【 摘 要 】

Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach.

【 授权许可】

Unknown