Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block

Molecules

Karol Michalak¹  Michał Michalak¹ 

[1] id="af1-molecules-10-01084">Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44, 01-224 Warszawa, Polan

关键词: Terpenes;    total synthesis;    cyclooctane derivatives;    ring closing metathesis;    Warner-Meerwein rearrangement;   

DOI  :  10.3390/10091084

来源: mdpi

【 摘 要 】

Sesqui- and sesterterpenes of ophiobolin and fusicoccin families are important synthetic targets because of complexity of structure and potentially useful physiological activities, including anti-tumor activity. A synthesis of versatile building blocks for these terpenoids is described. Cyclopenta[8]annulene rings system with properly dislocated substituents was constructed using as key steps ring closing metathesis reaction and Wagner - Meerwein rearrangement. Ring closing metathesis reaction leading to cyclopenta[8]annulene was studied in detail.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).