DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond

Genes

Donald T. Fox¹  Delisa E. Clay¹ 

[1] Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA;

关键词: DNA damage;    model organisms;    cell cycle;    DNA repair;   

DOI  :  10.3390/genes12121882

来源: DOAJ

【 摘 要 】

Genome damage is a threat to all organisms. To respond to such damage, DNA damage responses (DDRs) lead to cell cycle arrest, DNA repair, and cell death. Many DDR components are highly conserved, whereas others have adapted to specific organismal needs. Immense progress in this field has been driven by model genetic organism research. This review has two main purposes. First, we provide a survey of model organism-based efforts to study DDRs. Second, we highlight how model organism study has contributed to understanding how specific DDRs are influenced by cell cycle stage. We also look forward, with a discussion of how future study can be expanded beyond typical model genetic organisms to further illuminate how the genome is protected.

【 授权许可】

Unknown