Symptoms reported by SARS-CoV-2 seropositive and seronegative healthcare and administrative employees in Denmark from May to August 2020

International Journal of Infectious Diseases

Kent Jacob Nielsen¹  Thomas Greve²  Marianne Kragh Thomsen³  Holger Jon Møller⁴  Christian Erikstrup⁵  Jacob Dvinge Redder⁶  Kathrine Agergård Kaspersen⁶  Henrik Albert Kolstad⁷  Sanne Jespersen⁷  Lars Østergaard⁸  Jesper Medom Vestergaard⁸  Martin Tolstrup⁹  Susan Mikkelsen⁹ 

[1] Corresponding author at: Department of Clinical Immunology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.;Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, DK-4000 Roskilde, Denmark;Department of Occupational Medicine, Aarhus University Hospital, DK-8200 Aarhus N, Denmark;Business Intelligence, Central Denmark Region, DK-8200 Aarhus N, Denmark;Department of Clinical Biochemistry, Aarhus University Hospital, DK-8200 Aarhus N, Denmark;Department of Clinical Immunology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark;Department of Clinical Microbiology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark;Department of Infectious Diseases, Aarhus University Hospital, DK-8200 Aarhus N, Denmark;Department of Occupational Medicine, Herning Regional Hospital, DK-7400 Herning, Denmark;

关键词: SARS-CoV-2;    COVID-19;    Symptoms;    Prevalence;    Long-term symptoms;    Serosurvey;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: The distribution and nature of symptoms among SARS-CoV-2 infected individuals need to be clarified. Methods: Between May and August 2020, 11 138 healthcare and administrative personnel from Central Denmark Region were tested for SARS-CoV-2 antibodies and subsequently completed a questionnaire. Symptom prevalence and overall duration for symptoms persisting for more than 30 days were calculated. Logistic regression models were used to estimate adjusted odds ratios (ORs) with 95% CIs. Results: In total, 447 (4%) of the participants were SARS-CoV-2-seropositive. Loss of sense of smell and taste was reported by 50% of seropositives compared with 3% of seronegatives. Additionally, seropositives more frequently reported fever, dyspnoea, muscle or joint ache, fatigue, cough, headache and sore throat, and they were more likely to report symptoms persisting for more than 30 days. In adjusted models, they had a higher risk of reporting symptoms, with the strongest association observed for loss of sense of taste and smell (OR = 35.6; 95% CI: 28.6–44.3). Conclusion: In this large study, SARS-CoV-2-seropositive participants reported COVID-19-associated symptoms more frequently than those who were seronegative, especially loss of sense of taste and smell. Overall, their symptoms were also more likely to persist for more than 30 days.

【 授权许可】

Unknown