mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases

Viruses

Guijie Zhang¹  Xin Yin²  Chao Sun²  Jitao Chang²  Ting Le² 

[1] Departments of Animal Science, School of Agriculture, Ningxia University, Yinchuan 750021, China;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, China;

关键词: mRNA vaccine;    infectious disease;    zoonoses;    immune response;    viruses;   

DOI  :  10.3390/v14020401

来源: DOAJ

【 摘 要 】

In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise because of their low risk of insertional mutagenesis, high potency, accelerated development cycles, and potential for low-cost manufacture. In past years, several mRNA vaccines have entered clinical trials and have shown promise for offering solutions to combat emerging and re-emerging infectious diseases such as rabies, Zika, and influenza. Recently, the successful application of mRNA vaccines against COVID-19 has further validated the platform and opened the floodgates to mRNA vaccine’s potential in infectious disease prevention, especially in the veterinary field. In this review, we describe our current understanding of the mRNA vaccines and the technologies used for mRNA vaccine development. We also provide an overview of mRNA vaccines developed for animal infectious diseases and discuss directions and challenges for the future applications of this promising vaccine platform in the veterinary field.

【 授权许可】

Unknown