The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca2+ Waves in Cardiac Myocytes

Frontiers in Physiology

Yunlong Huo¹  Wenchang Tan²  Yundi Feng³  Xudong Chen³ 

[1] PKU-HKUST Shenzhen-Hong Kong Institution, Shenzhen, China;Shenzhen Graduate School, Peking University, Shenzhen, China;State Key Laboratory of Turbulence and Complex Systems and Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China;

关键词: Ca2+ wave;    Ca2+ quark;    anomalous subdiffusion;    rogue ryanodine receptors;    clustered ryanodine receptors;   

DOI  :  10.3389/fphys.2018.00393

来源: DOAJ

【 摘 要 】

Ca2+ waves in cardiac myocytes can lead to arrhythmias owing to delayed after-depolarisations. Based on Ca2+ regulation from the junctional sarcoplasmic reticulum (JSR), a mathematical model was developed to investigate the interplay of clustered and rogue RyRs on Ca2+ waves. The model successfully reproduces Ca2+ waves in cardiac myocytes, which are in agreement with experimental results. A new wave propagation mode of “spark-diffusion-quark-spark” is put forward. It is found that rogue RyRs greatly increase the initiation of Ca2+ sparks, further contribute to the formation and propagation of Ca2+ waves when the free Ca2+ concentration in JSR lumen ([Ca2+]lumen) is higher than a threshold value of 0.7 mM. Computational results show an exponential increase in the velocity of Ca2+ waves with [Ca2+]lumen. In addition, more CRUs of rogue RyRs and Ca2+ release from rogue RyRs result in higher velocity and amplitude of Ca2+ waves. Distance between CRUs significantly affects the velocity of Ca2+ waves, but not the amplitude. This work could improve understanding the mechanism of Ca2+ waves in cardiac myocytes.

【 授权许可】

Unknown