Frontiers in Physiology | |
The Interplay of Rogue and Clustered Ryanodine Receptors Regulates Ca2+ Waves in Cardiac Myocytes | |
Yunlong Huo1  Wenchang Tan2  Yundi Feng3  Xudong Chen3  | |
[1] PKU-HKUST Shenzhen-Hong Kong Institution, Shenzhen, China;Shenzhen Graduate School, Peking University, Shenzhen, China;State Key Laboratory of Turbulence and Complex Systems and Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China; | |
关键词: Ca2+ wave; Ca2+ quark; anomalous subdiffusion; rogue ryanodine receptors; clustered ryanodine receptors; | |
DOI : 10.3389/fphys.2018.00393 | |
来源: DOAJ |
【 摘 要 】
Ca2+ waves in cardiac myocytes can lead to arrhythmias owing to delayed after-depolarisations. Based on Ca2+ regulation from the junctional sarcoplasmic reticulum (JSR), a mathematical model was developed to investigate the interplay of clustered and rogue RyRs on Ca2+ waves. The model successfully reproduces Ca2+ waves in cardiac myocytes, which are in agreement with experimental results. A new wave propagation mode of “spark-diffusion-quark-spark” is put forward. It is found that rogue RyRs greatly increase the initiation of Ca2+ sparks, further contribute to the formation and propagation of Ca2+ waves when the free Ca2+ concentration in JSR lumen ([Ca2+]lumen) is higher than a threshold value of 0.7 mM. Computational results show an exponential increase in the velocity of Ca2+ waves with [Ca2+]lumen. In addition, more CRUs of rogue RyRs and Ca2+ release from rogue RyRs result in higher velocity and amplitude of Ca2+ waves. Distance between CRUs significantly affects the velocity of Ca2+ waves, but not the amplitude. This work could improve understanding the mechanism of Ca2+ waves in cardiac myocytes.
【 授权许可】
Unknown