The importance of physical fitness for the relationship of BDNF with obesity measures in young normal-weight adults

Heliyon

Khaldoon Alawneh¹  Omar F. Khabour²  Abubakar B. Maikano³  Karem H. Alzoubi⁴  Mahmoud A. Alomari⁵ 

[1] Corresponding author.;Division of Physical Therapy, Department of Rehabilitation Sciences, Jordan University of Science and Technology, Irbid, Jordan;Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan;Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Jordan;Department of Physical Education, Qatar University, Doha, Qatar;

关键词: Biological sciences;    Proteins;    Biochemistry;    Molecular biology;    Toxicology;    Pathophysiology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aims: Brain derived neurotrophic factor (BDNF) is essential for cognitive function. It is also found in non-neuronal tissues with various regulatory actions, including metabolic. Physical fitness (PF) is associated with improved synthesis and secretion of BDNF and reduced obesity. However, the importance of PF for the relationship of BDNF with obesity has not been investigated. This study aims at examining the relationship of PF with BDNF and obesity in 174 young (age = 25.30 ± 9.2 years) healthy adults. Main methods: Serum BDNF was evaluated using ELISA while obesity was determined using body weight (BW), BMI, and waist circumference (WC). Six minute walk distance (6MWD) test was used to estimate PF. Key findings: Serum BDNF was greater (p = 0.000) in the participants with high (Hi6MWD) versus low (Lw6MWD) PF group. Additionally, 6MWD explained 6.8% of serum BDNF. Obesity measures were greater (p < 0.05) in the participants with low versus high BDNF. In regression analyses, serum BDNF explained 4.7% of BW (p = 0.004), 3.8% of BMI (p = 0.011), and 6.2% of WC (p = 0.001). However, when the participants were divided into Hi6MWD and Lw6MWD, BDNF explained 8.2% of BW (p = 0.009), 6.0% of BMI (p = 0.03), and 7.0% of WC (p = 0.013), only in the Hi6MWD, but not in the Lw6MWD (p > 0.05) groups. Significance: The finding confirms the relationship of BDNF with obesity. Additionally, it further suggests the importance of PF level to this relationship among young adults. Future studies are needed to confirm these findings.

【 授权许可】

Unknown