The Study of Physicochemical Properties and Blood Compatibility of Sodium Alginate-Based Materials via Tannic Acid Addition

Materials

Adrianna Sosik¹  Anna Małkowska¹  Lidia Zasada¹  Beata Kaczmarek-Szczepańska¹  Marta Michalska-Sionkowska² 

[1] Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland;Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Veterinary Science, Nicolaus Copernicus University in Toruń, 87-100 Torun, Poland;

关键词: thin films;    sodium alginate;    tannic acid;    blood compatibility;   

DOI  :  10.3390/ma14174905

来源: DOAJ

【 摘 要 】

In this study, sodium alginate-based thin films were modified by the addition of tannic acid. Materials were obtained by solvent evaporation. They were characterized by the observation of its morphology and its surface by scanning electron microscope and atomic force microscope. The thermal properties were studied by differential scanning calorimetry. The concentration of tannic acid released from the material was determined by the Folin–Ciocalteu method. The material safety for biomedical application was determined by the hemolysis rate study in contact with sheep blood as well as platelet adhesion to the material surface. Based on the obtained results, we assume that proposed films based on sodium alginate/tannic acid are safe and may potentially find application in medicine.

【 授权许可】

Unknown