Thyroid Autoimmunity and Antiphospholipid Syndrome: Not Such a Trivial Association

Frontiers in Endocrinology

Mathilde Versini¹ 

[1] Department of Internal Medicine, Archet-1 Hospital, University Hospital of Nice, Nice, France;

关键词: antiphospholipid syndrome;    autoimmunity;    thyroid;    Hashimoto’s thyroiditis;    Graves’ disease;    autoimmune disease;   

DOI  :  10.3389/fendo.2017.00175

来源: DOAJ

【 摘 要 】

Antiphospholipid syndrome (APS) is an autoimmune disease that manifests as recurrent venous or arterial thrombosis and/or pregnancy-related complications in the presence of persistent antiphospholipid (aPL) antibodies measured at least 3 months apart. APS occurs either as a primary condition or as a part of an underlying disorder, usually systemic lupus erythematosus (SLE). Otherwise, APS may be frequently associated with autoimmune disorders. Little is known about the association of APS and aPL antibodies with thyroid autoimmune diseases or thyroid autoantibodies. This is even more interesting that thyroid autoantibodies and aPL are both recognized causes of repeated miscarriages. Therefore, their combination is of particular importance in women of childbearing age. Several studies have pointed out an association between APS and thyroid autoimmunity, some of them suggesting common pathophysiologic processes and genetic background. A literature review was conducted on existing data on aPL/APS and thyroid autoimmune disorders, paying particular attention to the possible role of this association in obstetrical complications.

【 授权许可】

Unknown