Effects of Lipopolysaccharide-Binding Protein (LBP) Single Nucleotide Polymorphism (SNP) in Infections, Inflammatory Diseases, Metabolic Disorders and Cancers

Frontiers in Immunology

Haoshu Fang¹  Leilei Meng¹  Zichen Song¹  Anding Liu²  Xiao Yang²  Uta Dahmen³ 

[1] Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China;Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Friedrich-Schiller-University Jena, Jena, Germany;

关键词: inflammation;    single nucleotide polymorphisms;    lipopolysaccharide-binding protein;    infections;    inflammatory diseases;    metabolic disorders;   

DOI  :  10.3389/fimmu.2021.681810

来源: DOAJ

【 摘 要 】

Inflammation, which is induced by the immune response, is recognized as the driving factor in many diseases, including infections and inflammatory diseases, metabolic disorders and cancers. Genetic variations in pivotal genes associated with the immune response, particularly single nucleotide polymorphisms (SNPs), may account for predisposition and clinical outcome of diseases. Lipopolysaccharide (LPS)-binding protein (LBP) functions as an enhancer of the host response to LPS, the main component of the outer membrane of gram-native bacteria. Given the crucial role of LBP in inflammation, we will review the impact of SNPs in the LBP gene on infections and inflammatory diseases, metabolic disorders and cancers.

【 授权许可】

Unknown