Lipopolysaccharide-binding protein, neopterin and interferon-gamma as indices of inflammation activity in patients with acute brucellosis

Žurnal Infektologii

O. V. Mahinja¹  N. S. Sarkisjan²  N. I. Kovalevich²  I. V. Sannikova³  M. V. Titorenko³ 

[1] City Polyclinic № 2, Stavropol;Stavropol Research anti Plague Institute of Rospotrebnadzor, Stavropol;Stavropol State Medical University, Stavropol;

关键词: brucellosis;    inflammation;    immune response;    lipopolysaccharide-binding protein;    neopterin;    interferon-γ;   

DOI  :  10.22625/2072-6732-2018-10-4-96-103

来源: DOAJ

【 摘 要 】

Brucellosis is characterized by nonspecific clinical manifestations, the possibility of subclinical flow, the development of relapses and chronic course. Currently, there are no laboratory criteria to assess the activity of inflammation in brucellosis, the effectiveness of the therapy, predict the outcome of the disease and the risks of recurrence. Available in clinical practice, laboratory tests to assess inflammation, in particular, erythrocyte sedimentation rate, C-reactive protein, leukocyte level, with brucellosis infection are almost not informative. An important role in the development of the cellular immune response against brucella is played by interferon-γ, lipopolysaccharide-binding protein and neopterin. The aim of the study was to determine the level of lipopolysaccharide-binding protein, neopterin and interferon-γ, in the serum of patients with acute form of brucellosis before and after antibacterial treatment. When studying the blood of patients with acute brucellosis before and after therapy, the indices of neopterin, lipopolysaccharide-binding protein and interferon-γ were significantly higher than normal values. The obtained results testify to the persisting active inflammation and the formation of a chronic brucellosis. Determination of the level of lipopolysaccharide-binding protein, neopterin and interferon-γ in the blood of patients with brucellosis can be used as markers of inflammation and in monitoring the effectiveness of antibacterial therapy.

【 授权许可】

Unknown