Review on the Current Trends of Toxoplasmosis Serodiagnosis in Humans

Frontiers in Cellular and Infection Microbiology

Adrian P. Ybañez¹  Rochelle Haidee D. Ybañez²  Yoshifumi Nishikawa² 

[1] Institute of Molecular Parasitology and Protozoan Diseases at Main and College of Veterinary Medicine, Cebu Technological University, Cebu City, Philippines;National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan;

关键词: Toxoplasma gondii;    toxoplasmosis;    serodiagnosis;    recombinant antigens;    human;   

DOI  :  10.3389/fcimb.2020.00204

来源: DOAJ

【 摘 要 】

Toxoplasmosis is a widely distributed zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii. It is mainly transmitted through the ingestion of oocysts shed by an infected cat acting as its definitive host. The key to effective control and treatment of toxoplasmosis is prompt and accurate detection of T. gondii infection. Several laboratory diagnostic methods have been established, including the most commonly used serological assays such as the dye test (DT), direct or modified agglutination test (DAT/MAT), indirect hemagglutination test (IHA), latex agglutination test (LAT), indirect immunofluorescent test (IFAT), enzyme-linked immunosorbent assays (ELISA), immunochromatographic tests (ICT), and the western blot. Nonetheless, creating specific and reliable approaches for serodiagnosis of T. gondii infection, and differentiating between acute and chronic phases of infection remains a challenge. This review provides information on the current trends in the serodiagnosis of human toxoplasmosis. It highlights the advantages of the use of recombinant proteins for serological testing and provides insight into the possible future direction of these methods.

【 授权许可】

Unknown