Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol

Systematic Reviews

on behalf of the Canadian Traumatic Brain Injury Research Consortium¹  Hourmazd Haghbayan²  Olivier Costerousse²  Alexis F. Turgeon²  Lynne Moore²  François Lauzier²  Mathieu Laflamme²  Malcolm R. Macleod³  Dean A. Fergusson⁴  Manoj M. Lalu⁴  Ryan Zarychanski⁵  Cheryl Wellington⁶  Jamie Hutchison⁷  Amélie Boutin⁸  Jacques Lacroix⁹ 

[1] ;CHU de Québec – Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma-Emergency-Critical Care Medicine), Université Laval;Centre for Clinical Brain Sciences, University of Edinburgh;Clinical Epidemiology Program, Ottawa Hospital Research Institute;Department of Internal Medicine, Sections of Critical Care Medicine, of Hematology and of Medical Oncology, Rady Faculty of Medicine, University of Manitoba;Department of Pathology and Laboratory Medicine, University of British Columbia;Department of Pediatrics, University of Toronto;Department of Pediatrics, Université Laval;Division of Pediatric Critical Care Medicine, Department of Pediatrics, Faculty of Medicine, Université de Montréal;

关键词: Red blood cell transfusion;    Blood products;    Traumatic brain injury;    Stroke;    Cerebral hemorrhage;    Animal models;   

DOI  :  10.1186/s13643-021-01703-8

来源: DOAJ

【 摘 要 】

Abstract Background Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models. Methods We will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE, and Web of Science databases for eligible studies from inception onwards. Two independent reviewers will perform study selection and data extraction. We will report our results in a descriptive synthesis focusing on characteristics of included studies, reported outcomes, risk of bias, and construct validity. Our primary outcome is the neurological function (neurobehavioral performance) and our secondary outcomes include mortality, infarct size, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and brain tissue oxygen tension. If appropriate, we will also perform a quantitative synthesis and pool results using random-effect models. Heterogeneity will be expressed with I 2 statistics. Subgroup analyses are planned according to animal model characteristics, co-interventions, and risks of bias. Discussion Our study is aligned with the efforts to better understand the level of evidence on the impact of red blood cell transfusion strategies from preclinical studies in animal models of acute brain injury and the potential translation of information from the preclinical to the clinical research field. Systematic review registration PROSPERO CRD42018086662 .

【 授权许可】

Unknown