Increased risk of ischemic stroke in patients with mild traumatic brain injury: a nationwide cohort study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Yung-Cheng Su²  Chen-Yang Hsu³  Ming-Yuan Huang¹  Chen-Wen Lee²  Yi-Kung Lee² 

[1] Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;Department of Public Heath, National Taiwan University, Taipei, Taiwan

关键词: National health insurance;    Traumatic brain injury;    Stroke;   

Others  :  1151687
DOI  :  10.1186/s13049-014-0066-y

 received in 2014-06-04, accepted in 2014-10-24,  发布年份 2014

【 摘 要 】

Background

It is known that the risk of stroke in patients with traumatic brain injury might be increased. However, the relationship between mild traumatic brain injury and ischemic stroke has never been established. We conducted a study of patients in Taiwan with mild traumatic brain injury to evaluate if they had a higher risk of stroke compared with the general population.

Methods

We utilized a sampled National Health Insurance claims database containing one million beneficiaries. We followed all adult beneficiaries older than 18 years from January 1, 2007 to December 31, 2010 to determine if they were diagnosed with ischemic stroke. We further identified patients with mild traumatic brain injury and compared their risk of ischemic stroke with the general population.

Results

We identified 24,905 patients with mild traumatic brain injury and 719,811 patients without mild traumatic brain injury. After controlling for age, gender, urbanization level, socioeconomic status, diabetes, hypertension, coronary artery disease, hyperlipidemia, history of alcohol intoxication, malignancies, heart failure, atrial fibrillation, smoking, obesity, epilepsy, peripheral artery disease and Charlson Comorbidity Index score, the adjusted hazard ratio for ischemic stroke was 1.46 (95% confidence interval, 1.33¿1.62).

Conclusion

Mild traumatic brain injury is an independent significant risk factor for ischemic stroke.

【 授权许可】

   
2014 Lee et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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