Inhibitory Effects of Cycloheterophyllin on Melanin Synthesis

Molecules

Joong-Hyun Shim¹ 

[1] Department of Cosmetic Science, Semyung University, Science & Engineering Bldg/Room 313, Chungbuk 390-711, Korea;

关键词: cycloheterophyllin;    melanin;    tyrosinase;    microphthalmia-associated transcription factor;   

DOI  :  10.3390/molecules26092526

来源: DOAJ

【 摘 要 】

This study was performed to clarify the inhibitory effects of cycloheterophyllin on melanin synthesis. In order to elucidate the inhibitory effects of cycloheterophyllin on the B16F10 cell line, cell viability, messenger ribonucleic acid (mRNA) expressions, tyrosinase activity assay, and melanin production assay were measured. The effects of cycloheterophyllin on tyrosinase-related protein 1 (TYRP1)/TYRP2/tyrosinase (TYR)/microphthalmia-associated transcription factor (MITF) mRNA expressions and melanin content were determined. Quantitative real-time RT-PCR showed that cycloheterophyllin decreased the mRNA expression level of TYRP1/TYRP2/TYR/MITF genes and melanin production contents than α-MSH-treated B16F10 cells. The tyrosinase activity assay revealed that cycloheterophyllin decreased the melanin production in the B16F10 cells. These data show that cycloheterophyllin increases the whitening effects in the B16F10 cells; thus, cycloheterophyllin is a potent ingredient for skin whitening. Thus, further research on the mechanism of action of cycloheterophyllin for the development of functional materials should be investigated.

【 授权许可】

Unknown