Circulating MicroRNAs in Cancer: Potential and Challenge

Frontiers in Genetics

Hongdan Wang¹  Dan Zhang²  Yingjun Xie²  Xuewen Zhang²  Mengying Cui²  Xiaoxiao Yao²  Ranji Cui³ 

[1] Department of Anesthesiology, The First Hospital of Jilin University, Changchun, China;Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China;Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China;

关键词: miRNAs;    circulating;    cancer;    biomarker;    communication;    therapy;   

DOI  :  10.3389/fgene.2019.00626

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or pathological status. The quality and quantity changes of circulating miRNAs are associated with the initiation and progression of cancer and can be easily detected by basic molecular biology techniques. Consequently, considerable effort has been devoted to identify suitable extracellular miRNAs for noninvasive biomarkers in cancer. However, several challenges need to be overcome before the practical application. In this review, we discuss several issues of circulating miRNAs: biological function and basic transport carriers; extracellular cell communication process; roles as reliable cancer biomarkers and usage in targeted cancer therapy; and challenges for clinical application.

【 授权许可】

Unknown