Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection

International Journal of Molecular Sciences

Yanning Ma¹  Xian Wang¹ 

[1] Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China;

关键词: cancer;    biomarker;    DNA methylation;    miRNAs;   

DOI  :  10.3390/ijms140510307

来源: mdpi

【 摘 要 】

Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland