Marine Drugs | |
Chemistry and Biology of Siderophores from Marine Microbes | |
Huawei Zhang1  Bixia Wang1  Yuqi Guo1  Jiadong Sun2  Yaojia Lu2  Hong Wang2  Jianwei Chen2  | |
[1] Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China;;College of Pharmaceutical Science & | |
关键词: siderophores; marine microbes; synthesis; biosynthesis; | |
DOI : 10.3390/md17100562 | |
来源: DOAJ |
【 摘 要 】
Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine microbes to proliferate and survive in the iron-deficient marine environments. Due to their unique iron(III)-chelating properties, delivery system, structural diversity, and therapeutic potential, marine microbial siderophores have great potential for further development of various drug conjugates for antibiotic-resistant bacteria therapy or as a target for inhibiting siderophore virulence factors to develop novel broad-spectrum antibiotics. This review covers siderophores derived from marine microbes.
【 授权许可】
Unknown