Chemistry and Biology of Siderophores from Marine Microbes

Marine Drugs

Huawei Zhang¹  Bixia Wang¹  Yuqi Guo¹  Jiadong Sun²  Yaojia Lu²  Hong Wang²  Jianwei Chen² 

[1] Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China;;College of Pharmaceutical Science &

关键词: siderophores;    marine microbes;    synthesis;    biosynthesis;   

DOI  :  10.3390/md17100562

来源: DOAJ

【 摘 要 】

Microbial siderophores are multidentate Fe(III) chelators used by microbes during siderophore-mediated assimilation. They possess high affinity and selectivity for Fe(III). Among them, marine siderophore-mediated microbial iron uptake allows marine microbes to proliferate and survive in the iron-deficient marine environments. Due to their unique iron(III)-chelating properties, delivery system, structural diversity, and therapeutic potential, marine microbial siderophores have great potential for further development of various drug conjugates for antibiotic-resistant bacteria therapy or as a target for inhibiting siderophore virulence factors to develop novel broad-spectrum antibiotics. This review covers siderophores derived from marine microbes.

【 授权许可】

Unknown