期刊论文详细信息
Neurobiology of Disease
High beta activity in the subthalamic nucleus and freezing of gait in Parkinson's disease
Jorge Guridi1  Manuel Alegre2  Miguel Valencia3  Jose Obeso4  Jon López-Azcárate4  Jon B. Toledo4  David Garcia-Garcia4  Julio Artieda4  Maria Rodriguez-Oroz4 
[1] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain;Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain;Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain;Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain;
关键词: Freezing of gait;    Parkinson's disease;    Oscillatory activity;    Subthalamic nucleus;    Beta activity;   
DOI  :  
来源: DOAJ
【 摘 要 】

Objective: Oscillatory activity in the beta band is increased in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients. Rigidity and bradykinesia are associated with the low-beta component (13–20 Hz) but the neurophysiological correlate of freezing of gait in PD has not been ascertained. Methods: We evaluated the power and coherence of the low- and high-beta bands in the STN and cortex (EEG) of PD patients with (p-FOG) (n = 14) or without freezing of gait (n-FOG) (n = 8) in whom electrodes for chronic stimulation in the STN had been implanted for treatment with deep brain stimulation. Results: p-FOG patients showed higher power in the high-beta band (F = 11.6, p = 0.002) that was significantly reduced after l-dopa administration along with suppression of FOG (F = 4.6, p = 0.042). High-beta cortico-STN coherence was maximal for midline cortical EEG electrodes, whereas the low-beta band was maximal for lateral electrodes (χ2 = 20.60, p < 0.0001). Conclusions: The association between freezing of gait, high-beta STN oscillations and cortico-STN coherence suggests that this oscillatory activity might interfere in the frontal cortex–basal ganglia networks, thereby participating in the pathophysiology of FOG in PD.

【 授权许可】

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