Potential Influences of RNF6 on Prognosis and Metastasis of Colorectal Cancer: A Clinical Analysis

OncoTargets and Therapy

关键词: rnf6;    e-cadherin;    crc;    metastasis;    survival;   

DOI  :  

来源: DOAJ

【 摘 要 】

Huili Zhu, Chunhui Wang Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Chunhui WangDepartment of Gastroenterology, West China Hospital, Sichuan University, GuoXue Street 37, Chengdu 610041, People’s Republic of ChinaTel [phone]Email [e-mail]: Ring finger protein 6 (RNF6) locates on the chromatin 13q.12.13, where amplification is frequently occurred in colorectal cancer (CRC). Previous studies have reported the role of RNF6 to accelerate the progression and metastasis of CRC.Methods: In this paper, we mainly analyzed the potential of RNF6 to predict the prognosis and metastasis of CRC. Based on the cut-off value of RNF6, enrolled CRC patients were assigned into high- and low-level group. Correlation between RNF6 level and survival of CRC patients was assessed.Results: Our findings revealed that RNF6 was upregulated in CRC tissues. IHC staining demonstrated higher positive expression of RNF6 in CRC tissues. Nearly 61.2% CRC patients had a positive expression of RNF6. Moreover, RNF6 was closely linked to lymphovascular invasion (LV) (P=0.006), invasion depth (P=0.001), metastasis (P< 0.001) and TNM staging (P< 0.001). In CRC tissues, RNF6 level was negatively correlated to that of E-cadherin (r=− 0.7093, P< 0.0001). OS (overall survival) and RFS (recurrence-free survival) were worse in CRC patients with high-level RNF6, and tumor cell metastasis was believed to be the major reason.Conclusion: Therefore, RNF6 was confirmed to be a hallmark predicting the prognosis and metastasis in CRC patients.Keywords: RNF6, E-cadherin, CRC, metastasis, survival

【 授权许可】

Unknown