TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

Cell Adhesion & Migration

Liangliang Xiang¹  Tengyang Ni¹  Weimin Wang¹  Dan Li¹  Li Tao¹  Yan Zhou¹  Mengying Lv¹  Yanqing Liu¹  Sunagawa Masatara²  Jianliang Deng³  Xiancheng Gu³ 

[1] Medical College, Yangzhou University;School of Medicine, Showa University;Yixing Hospital Affiliated to Medical College of Yangzhou University;

关键词: crc;    timp-2;    mmp-9;    prognosis;    metastasis;   

DOI  :  10.1080/19336918.2019.1639303

来源: DOAJ

【 摘 要 】

Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a  CRC tissue microarray by immunohistochemistry. We found that lower TIMP-2 or/and higher MMP-9 expression in cancer tissues was correlated with poorer overall survival (OS). TIMP-2 or MMP-9 expression was independent prognostic factors for CRC. Furthermore, TIMP-2 and MMP-9 expression had a synergistic role as efficient prognostic indicators for CRC patients. In vitro and in vivo, TIMP-2 could inhibit HCT 116 cells invasion and migration by regulating MMP-9. In sum, a combined expression of TIMP-2 and MMP-9 as efficient prognostic indicators was found for the first time.

【 授权许可】

Unknown