Predictive role of vitamin A serum concentration in psoriatic patients treated with IL-17 inhibitors to prevent skin and systemic fungal infections

Journal of Pharmacological Sciences

Cosio Terenzio¹  Bianchi Luca²  Campione Elena³  Lanna Caterina³  Mazzilli Sara³  Ventura Alessandra³  Candi Eleonora³  Dika Emi⁴  Gaziano Roberta⁵  Dattola Annunziata⁶ 

[1] Corresponding author. Dermatologic Unit, Department of Systems Medicine University of Rome Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.;Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy;Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;Dermatologic Unit, University of L'Aquila, L'Aquila, Italy;Dermatology Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy;Microbiology Section, Department of Experimental Medicine and Surgery, University of Rome “Tor Vergata”, Rome, Italy;

关键词: All-trans retinoic acid;    Vitamin A;    Interleukin 17;    Interleukin-17 inhibitors;    Fungal pathogens;    Psoriasis;   

DOI  :  

来源: DOAJ

【 摘 要 】

The use of biological drugs in psoriasis is replacing traditional therapies due to their specific mechanism and limited side effects. However, the use of Interleukin 17 inhibitors and the modification of its cytokine pathway could favor the risk of fungal infections.All-trans retinoic acid is an active metabolite of vitamin A with anti-inflammatory and immunoregulatory properties through its capacity to stimulate both innate and adaptive immunity and to its effects on proliferation, differentiation and apoptosis in a variety of immune cells. Furthermore, it has been recently discovered that All-trans retinoic acid has a direct fungistatic effect against Candida and Aspergillus Fumigatus.On the basis of these new insights, in the current review, we suggest that the evaluation of serum level of All-trans retinoic acid or vitamin A should be considered as a predictive marker for the development of fungal infections among psoriatic patients treated with Interleukin 17 inhibitors.In clinical practice, vitamin A test could be added in the routine hospital diagnostic management for a better selection of psoriatic patients eligible to Interleukin 17 inhibitors.

【 授权许可】

Unknown