CD161 expressing human T cells

Frontiers in Immunology

Paul eKlenerman¹  Joannah R Fergusson²  Vicki M Fleming² 

[1] John Radcliffe Hospital;University of Oxford;

关键词: NK cells;    T cells;    Interleukin 17;    CD161;    NKRP1;    NK-T cells;   

DOI  :  10.3389/fimmu.2011.00036

来源: DOAJ

【 摘 要 】

Expression of the Natural Killer cell receptor CD161 has recently been identified on a subset of T cells, including both CD4+ T helper and CD8+ cytotoxic T cells.Expression of this molecule within the adult circulation is restricted to those T cells with a memory phenotype.However, the distinct properties of these T cell populations is yet to be fully determined, although expression of CD161 has been related to the secretion of interleukin 17, and therefore to a type 17 phenotype.Recent studies have aimed to determine both the origin of these cells and the significance of CD161 expression as either a marker of specific cell types or as an effector and regulator of lymphocyte function, and hence to characterise the role of these CD161+ cells within a variety of human diseases in which they have been implicated.

【 授权许可】

Unknown