Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products

Microorganisms

卷:5

Yohei Watanabe¹  Tomonori Kamiya¹  Noriko M Tsuji¹  Seiya Makino²  Hiroshi Kano² 

[1] Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan;

[2] Food Science Research Laboratories, Meiji Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan;

关键词: Lactic acid bacteria;    Peyer’s patches;    Dendritic cells;    T helper cells;    Lactobacillus bulgaricus;    Streptococcus thermophilus;    Interferon γ;    Interleukin 17;    Mucosal immunity;    Probiotics;   

DOI  :  10.3390/microorganisms5010001

来源: DOAJ

【 摘 要 】

Lactic acid bacteria (LAB) form a major component of gut microbiota and are often used as probiotics for fermented foods, such as yoghurt. In this study, we aimed to evaluate immunomodulatory activity of LAB, especially that of Lactobacillus bulgaricus ME-552 (ME552) and Streptococcus thermophilus ME-553 (ME553). In vivo/in vitro assay was performed in order to investigate their effects on T cell function. After oral administration of ME553 to C57BL/6 mice, the amount of both interferon γ (IFN-γ) and interleukin 17 (IL-17) produced by cluster of differentiation (CD) 4+ T cells from Peyer’s patches (PPs) were significantly enhanced. On the other hand, ME552 only up-regulated the production of IL-17 from PP cells. The extent of induction for IFN-γ production differed between ME552 and ME553. These results suggest that LAB modulate T cell effector functions and mucosal immunity.

【 授权许可】

Unknown