Fish Immunoglobulins

Biology

Sara Mashoof¹  Michael F. Criscitiello² 

[1] Comparative Immunogenetics Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA;

关键词: immunoglobulin;    evolution;    fish;    teleost;    immunoglobulin heavy chain;    immunoglobulin light chain;    shark;    antibody;    natural selection;    humoral immunity;   

DOI  :  10.3390/biology5040045

来源: DOAJ

【 摘 要 】

The B cell receptor and secreted antibody are at the nexus of humoral adaptive immunity. In this review, we summarize what is known of the immunoglobulin genes of jawed cartilaginous and bony fishes. We focus on what has been learned from genomic or cDNA sequence data, but where appropriate draw upon protein, immunization, affinity and structural studies. Work from major aquatic model organisms and less studied comparative species are both included to define what is the rule for an immunoglobulin isotype or taxonomic group and what exemplifies an exception.

【 授权许可】

Unknown