Evidence for Peripheral Immune Activation in Parkinson’s Disease

Frontiers in Aging Neuroscience

Qianqian Wei¹  Jiao Liu¹  Ruwei Ou¹  Jing Yang¹  Yongping Chen¹  Jiajia Fu¹  Xueping Chen¹  Bei Cao¹  Huifang Shang¹  Weihua Feng² 

[1] Department of Neurology, West China Hospital, Sichuan University, Chengdu, China;Division of Clinical Immunology, West China Hospital, Sichuan University, Chengdu, China;

关键词: humoral immune;    cellular immune;    Parkinson’s disease;    disease process;    peripheral immunity;   

DOI  :  10.3389/fnagi.2021.617370

来源: DOAJ

【 摘 要 】

BackgroundAccumulating evidence has revealed that peripheral immunity is involved in Parkinson’s disease (PD). However, the results regarding the percentage of T-cell subsets are inconsistent, and the changes of immunoglobins levels have been seldom studied in PD patients.MethodsSerum levels of the percentage of T-cell subsets and immunoglobulins were measured in 761 PD patients and 761 age- and gender-matched healthy controls. The correlations between the variables of peripheral immune activation (PIA) and the clinical characteristics of PD were analyzed using correlation analysis.ResultsThe pooled results showed that PD patients had higher proportional levels of CD3+ T and CD4+ T lymphocytes than healthy controls. CD8+ T cell percentages were similar in PD patients and controls, and the CD4/CD8 ratio was significantly higher in the PD population. No significant differences in IgG, IgA, or IgM levels between these two groups were found. CD4+ T cell percentage was inversely correlated with the H&Y stage, and IgG level was positively correlated with disease duration and UPDRS part III. Subgroup analyses showed that these associations existed in female patients, but not in male patients.ConclusionThe enhanced immune activation in the peripheral system is indicated in PD, and dynamic alterations in CD4+ T cell percentage and IgG level suggest an active role for peripheral immunity in the disease progression, especially in female PD patients.

【 授权许可】

Unknown