Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice

Molecules

Jing Lu¹  Shuang Guan¹  Xue Shen¹  Wenhui Qian¹  Guoren Huang¹  Xuming Deng¹ 

[1] ¹Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China ²Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, China ^†These authors should be regarded as joint first author.

关键词: immunosuppression;    8-gingerol;    humoral immune;    cellular immune;   

DOI  :  10.3390/molecules16032636

来源: mdpi

【 摘 要 】

8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only significantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19⁺ B cells and CD3⁺ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-specific IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.