Current therapeutic strategies for respiratory diseases using mesenchymal stem cells

MedComm

Zhi‐yao Zheng¹  Zhi‐dong Zhang¹  Ming‐yao Wang¹  Hao‐yang Liu¹  Ting‐yue Zhou¹  Hui‐qi Xie¹ 

[1] Laboratory of Stem Cell and Tissue Engineering Orthopedic Research Institute Med‐X Center for Materials State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu China;

关键词: acute respiratory distress syndrome;    asthma;    chronic obstructive pulmonary disease;    idiopathic pulmonary fibrosis;    mesenchymal stem cells;   

DOI  :  10.1002/mco2.74

来源: DOAJ

【 摘 要 】

Abstract Mesenchymal stromal/stem cells (MSCs) have a great potential to proliferate, undergo multi‐directional differentiation, and exert immunoregulatory effects. There is already much enthusiasm for their therapeutic potentials for respiratory inflammatory diseases. Although the mechanism of MSCs‐based therapy has been well explored, only a few articles have summarized the key advances in this field. We hereby provide a review over the latest progresses made on the MSCs‐based therapies for four types of inflammatory respiratory diseases, including idiopathic pulmonary fibrosis, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and asthma, and the uncovery of their underlying mechanisms from the perspective of biological characteristics and functions. Furthermore, we have also discussed the advantages and disadvantages of the MSCs‐based therapies and prospects for their optimization.

【 授权许可】

Unknown